The Jiggins Lab Webpage

Samuel H. Lewis

Research Interests

Genetic conflicts often occur between a host and a parasite, and can drive dynamic and rapid evolution of both the host and the parasite. I investigate how these conflicts evolve at the genetic level using population genetics, comparative genomics and experimental validation of function. I am currently focusing on how conflict with viruses and transposons, which act as genetic parasites, drives the evolution of a host defence mechanism known as the RNAi pathway. I am investigating this conflict across many different arthropod species, to estimate the speed and frequency with which host defence mechanisms can evolve, and to characterise the variation that this evolution can produce.

Personal Website

Education and Employment

2015-present: Post-Doctoral Research Associate, Department of Genetics, University of Cambridge

2011-2015: Graduate Student, Institute of Evolutionary Biology, University of Edinburgh

2007-2011: BSc (Hons) Zoology with Industrial Placement, University of Manchester

July-Aug 2010: Research Assistant, The Natural History Museum, London

Sept 2009-June 2010: Research Assistant, Succulent Karoo Research Station, South Africa


Lewis SH, Salmela H & Obbard DJ (2016) Duplication and diversification of Dipteran Argonaute genes, and the evolutionary divergence of Piwi and Aubergine Genome Biology and Evolution

Lewis SH & Obbard DJ (2015) Recent insights into the evolution of innate viral sensing in animals Current Opinion in Microbiology 20C:170-175

Schnettler E, Tykalova H, Watson M, Sharma M, Sterken MG, Obbard DJ, Lewis SH et al (2014) Induction and suppression of tick cell antiviral RNAi responses by tick-borne flaviviruses Nucleic Acids Research 42:9436-9446

Lewis SH, Salmela H & Obbard DJ (in prep) Strong selection and testis specialization following repeated duplication of Drosophila Argonaute2


PDFs available on my website. If you cannot access something, feel free to email me.

Google Scholar Citations