Force Generation Principles
Jul 2014 Our opinion article on spindle orientation is here now. Congrats to Selina, K and Jo! Selina and K were Part II students at Genetics.
Jun 2014 Our TAO1 paper is here now. Congrats to Roshan, Naoka, Jo, Anna & Nicolas! Anna was a Part II student at Genetics.
May 2014 Jo's special cake for celebrating our new paper on TAO1's role in mitosis and microtubule regulation.
Apr 2014 Duccio from our group gave an invited talk at Robinson College on "Aneuploidy and cancer: the role of phosphatases in chromosome segregation"
Mar 2014 Naoka is Dr. Tamura Now Congrats Naoka.
Aug 2013 Our paper on the end-on conversion process at Current Biology.
Jul 2013 Our paper on the two regimes of spindle movement in Cell Cycle.
Regulated sub-cellular movements are a fundamental aspect of all living cells and they rely on precisely controlled force generation mechanisms. How are forces imparted, monitored and corrected in response to heterogeneous biochemical and physical cues is a fascinating and challenging biological problem. We address these fundamental questions in the context of dividing human cells and apply the molecular knowledge on force generation and cell division to accelerate cytoskeletal drug discovery and drug resistance biomarker research.
Defective force generation during cell division can lead to chromosomal instability and errors in the size, content and fate of daughter cells. Our research findings are therefore relevant to the understanding of irregular chromosome numbers (aneuploidy) and tissue disorganisation found in aggressive cancers and several age-related disorders.
We combine single-cell microscopy with molecular and biochemical approaches. We collaboratively develop computational tools to extract single-cell and population metrics. These approaches form the platform for two streams of studies in our group: (i) To investigate how microtubules are correctly anchored and force generation controlled to power the movements of chromosomes and mitotic spindle, we use high-resolution live-cell imaging of human cells. (ii) To translate the basic knowledge on mitotic microtubule regulation into accelerating the discovery of novel microtubule perturbing drugs and drug resistance biomarkers, we perform pharmacogenomics studies. We are currently refining transcriptional signatures that can predict cells sensitive to Paclitaxel. Visit ongoing research projects for more information.
PhD, MPhil and Post-doctoral opportunities are open. For more information write to:
The Issac Newton Trust